Bioactive Small Molecules
Medchemexpress LLC PqsR/LasR-IN-1 | 924818-33-7 | 98.1% | 405.87 | 25 MG
PqsR/LasR-IN-1 is a potent inhibitor of PqsR and LasR systems. It demonstrates anti-virulence activity against *Pseudomonas aeruginosa*, reducing the production of biofilm, pyocyanin, and rhamnolipids in PA.
- Potent PqsR and LasR systems inhibitor
- Exhibits anti-virulence activity against *Pseudomonas aeruginosa*
- Reduces production of biofilm in PA
- Reduces production of pyocyanin in PA
- Reduces production of rhamnolipids in PA
Medchemexpress LLC 5'-ODMT cEt G Phosphoramidite (Amidite) | 945628-66-0 | 99.1% | 881.95 | 250 MG
5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog that demonstrates excellent safety and antisense activity. It is intended for research use only.
- Enhances RNA-binding ability
- Affects the construction of antisense oligonucleotides (ASOs)
- Reduces ASO toxicity through alterations in nucleotide conformation and 5'-alkyl DNA modification
Medchemexpress LLC KS100 | 2408477-54-1 | 99.6% | 564.09 | 25 MG
KS100 is a potent ALDH inhibitor with IC50 values of 230 nM for ALDH1A1, 1542 nM for ALDH2, and 193 nM for ALDH3A1. It demonstrates antiproliferative and anticancer effects with low toxicity, increasing ROS activity, lipid peroxidation, and toxic aldehyde accumulation. It also induces apoptosis and cell cycle arrest at the G2/M phase.
- Potent ALDH inhibitor targeting ALDH1A1, ALDH2, and ALDH3A1
- Exhibits antiproliferative and anticancer effects
- Low toxicity
- Increases ROS activity, lipid peroxidation, and toxic aldehyde accumulation
- Induces apoptosis and cell cycle arrest at the G2/M phase
Medchemexpress LLC JNJ-28583113 | 2765255-93-2 | >98.8% | 366.38 | 250 MG
JNJ-28583113 is a brain-permeable TRPM2 antagonist. It inhibits TRPM2-blocked phosphorylation of GSK3α and β subunits, protects cells from oxidative stress-induced cell death, and suppresses cytokine release in response to pro-inflammatory stimuli in microglia.
- Inhibits TRPM2 in cells (IC50=100 nM chimpanzee, 25 nM rat, 126 nM human)
- Prevents cells from H2O2 induced cell death up to 1 mM of H2O2
- Protects HeLa cells from H2O2 induced morphological changes
- Brain penetrant and achieves 400 ng/mL in the brain compartment
Medchemexpress LLC PROTAC eEF2K degrader-1 | 2458170-54-0 | 98.6% | 707.65 | 25 MG
PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells and mediates eEF2K degradation. It is intended for research use only.
- eEF2K-Targeting PROTAC small molecule
- Induces apoptosis in MDA-MB-231 cells
- Mediates eEF2K degradation
- Solid, white to off-white in color
- Soluble in DMSO at 25 mg/mL
- Targets CaMK III/eEF-2K
Medchemexpress LLC Parp1-in-8 | 836640-15-4 | 99.3% | 403.86 | 25 MG
PARP1-IN-8 is a potent and BBB-penetrated PARP1 inhibitor with an IC50 of 97 nM. It demonstrates significant anti-proliferative activity against human lung adenocarcinoma epithelial cell line A549, and does not display significant cytotoxicity on HFF cells.
- Potent, BBB-penetrated PARP1 inhibitor
- IC50 of 97 nM
- Significantly potent anti-proliferative activity against A549 cells
- No significant cytotoxicity on HFF cells
Medchemexpress LLC 1H-Imidazole-1-acetonitrile, 2-[[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]thio]- | 2418577-51-0 | 99.6% | 315.35 | 25 MG
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor (IC50 of 7.13 μM). It decreases PC-3 cell migration with low cytotoxicity.
- Potent Cathepsin X inhibitor.
- IC50 of 7.13 μM against Cathepsin X.
- Decreases PC-3 cell migration.
- Exhibits low cytotoxicity.
- For research use only.
- Purity: 99.62%.
- Molecular weight: 315.35.
- Formula: C15H13N3O3S.
- CAS no.: 2418577-51-0.
- Appearance: Solid, white to off-white.
- Storage: 4°C (protected from light); in solvent: -80°C (6 months), -20°C (1 month), protected from light.
- Soluble in DMSO (≥ 100 mg/mL); soluble in H2O (4.85 mg/mL) with ultrasonic, warming, and adjusting pH to 3 with HCl and heating to 60°C.
Medchemexpress LLC Insulin (cattle) | 11070-73-8 | 98.4% | 5800 | 25 MG
Insulin (cattle) is a two-chain polypeptide hormone produced by the pancreatic β cells. It is commonly used as a growth supplement in cell culturing. In vitro, the α and β chains are joined by two interchain disulfide bonds, and the α chain contains an intrachain disulfide bond. This hormone regulates glucose uptake into muscle and fat cells by recruiting membrane glucose transporter Glut-4 to the cell surface. It has been effectively utilized in cell cultures at concentrations ranging from 1 to 10 μg/mL.
- Two-chain polypeptide hormone
- Produced by pancreatic β cells
- Used as a growth supplement in cell culturing
- Regulates glucose uptake into muscle and fat cells
- Recruits membrane glucose transporter Glut-4 to the cell surface
- Effective for cell culturing at 1 to 10 μg/mL concentration
Medchemexpress LLC EXP3179 50mg | 114798-36-6 | 420.89 g/mol | C22H21ClN6O | 50 MG
EXP3179 (losartan carboxaldehyde) is an aldehyde metabolite of losartan that inhibits endothelial cyclooxygenase-2 (COX-2). Supplied as a white to off-white solid for research use, it is intended for studies of inflammation and vascular biology.
- High purity (98.09%).
- Molecular formula C22H21ClN6O; molecular weight 420.89 g/mol.
- Supplied as 50 mg powder.
- Appearance: white to off-white solid.
- Storage: powder -20°C (3 years); in solvent -80°C (6 months), -20°C (1 month).
- For research use only; not for human or clinical use.
Medchemexpress LLC VU0424465 10mM | 10MM 1ML
VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2 mobilization VU0424465 exhibits high affinity at MPEP allosteric binding site with a Ki value of 11 8 nM VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2]
Medchemexpress LLC SN05 | 2768663-51-8 | 98.37% | 311.33 | 25 MG
SN05 is a potent amino acid transport (AAT) inhibitor with Ki values for various human and rat ASCT and EAAT transporters. This compound can be used in the study of cancer.
- Potent amino acid transport inhibitor
- Inhibits hASCT1, rASCT2, hASCT2, EAAT1, EAAT2, EAAC1, and EAAT5 transporters
- Ki values from 0.73 μM to 7.25 μM for target transporters
- Useful in cancer research
![Medchemexpress LLC Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimi | 2307249-33-6 | 99.3% | 515.53 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000436047-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimi | 2307249-33-6 | 99.3% | 515.53 | 50 MG
BAY885 is a chemical probe that acts as a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. It exhibits weak inhibition on other kinases. It has been shown to have potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and did not affect a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM).
- Highly potent and selective ERK5 inhibitor
- IC50 of 35 nM for ERK5
- Weak inhibition on other kinases
- Suitable for research use only
Selleck Chemical LLC VR23 5mg 1624602-30-7
VR23 is a potent proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 ?M for trypsin-like proteasomes, chymotrypsin-like proteasomes, and caspase-like proteasomes, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical N-1- 2 3-DIoleyloxypropyl- 5mg
A cationic lipid; has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro
Apexbio Technology LLC Doripenem 148016-81-3 50mg
Doripenem (148016-81-3) is a small-molecule inhibitor targeting penicillin-binding proteins (PBPs) It is designed to inhibit bacterial cell wall peptidoglycan synthesis thereby impairing cell wall integrity Doripenem exerts its biological activity primarily through inhibition of bacterial cell wall synthesis by binding to essential PBPs In in vitro studies Doripenem demonstrates inhibitory activity with IC50 values typically in the low micromolar range against representative bacterial isolates Based on these pharmacological properties Doripenem holds research potential in investigating microbial resistance mechanisms evaluating beta-lactamase enzyme inhibition and studying pharmacokinetic/pharmacodynamic profiles relevant to antimicrobial development